Fight Aging!
Treatment of Aging Will Require Combined Therapies, But Haphazard Combination Doesn't Work
Autophagy as a Double Edged Sword in Aging
How One Class of Inflammatory Microbes in the Aging Gut Microbiome Degrades Memory Function
Prevalence of Roseburia Inulinivorans in the Gut Microbiome Affects Muscle Strength
Evidence for Microglia to Actively Promote Amyloid Aggregation in the Aging Brain
Exercise Modifies the Gut Microbiome and Tryptophan Metabolism to Improve Mood and Memory
Interfering in Induction of Bystander Senescence as an Approach to Senotherapy
The Signatures of Different Senescent Cell Types Exhibit Different Strengths of Correlation with Age-Related Conditions
IGFBP7 Secreted by Senescent Cells Suppresses the Benefits of Exercise
Fight Aging! Newsletter, March 16th 2026
A Preprint Claiming Exceptional Extension of Life in Mice via a Telomere Transfer Mechanism
Investigating the Early Stages of Age-Related Cataract Formation
In an Average Decline of Function, Some Old People Exhibit Improved Function
Some Spiny Mouse Species are Long-Lived in Addition to Displaying Exceptional Regeneration
Injectable Mini-Livers as an Alternative to Liver Regeneration
Limited Food, Declining Glycolytic ATP Production, and the Evolution of Aging
A Better View of How Cells Take Up Mitochondria to Restore Function
Arguing for PPARα Agonist Fenofibrate to be Geroprotective
Periodontitis Alters the Gut Microbiome to Accelerate Osteoporosis
ANKRD1 Gene Therapy Improves Memory Function in Aged Mice
The Hypoxia Response as an Example of the Way in Which Mild Stressors Slow Aging
A View of the Present State of the Comparative Biology of Aging
Complement System Biomarkers Change with Age, and More So in Dementia Patients
Electric Fields Allow Bioprinting of Aligned Muscle Fibers
A SEMA7A Feedback Loop in Macrophages Accelerates Atherosclerosis
Fight Aging! Newsletter, March 9th 2026
Reviewing What is Known of the Virome in Aging
FMO-2 Upregulation is Common to Multiple Longevity Associated Mutations in Nematodes
More Confirming Data for Adult Human Neurogenesis
Microbiome Depletion in Aged Mice Reverses Aspects of the Aging of the Brain
Circular RNA MT-RNR2 in Mitochondrial Function and Aging
Enhancing Mitochondrial Function Improves Memory in Flies and Mice
A Fair Amount of ARPA-H Funding is Being Used for Clinical Trials Relevant to Aging
TDP-43 Aggregation as a Feature of Vascular Dementia
Circulating Piwi-Interacting RNA Levels Correlate with Survival in Old People
Distinct Nuclear DNA Structure in Immune Cells from Centenarians
The Role of the cGAS-STING Interaction in the Age-Related Inflammation of the Brain
Some Epigenetic Clocks Correlate with Risk of Dementia
The Relevance of Clonal Hematopoiesis to Degenerative Aging Remains Uncertain
Fight Aging! Newsletter, March 2nd 2026
Changes in the Gut Microbiome Drive Age-Related Intestinal Barrier Dysfunction
Women Exhibit Less Atherosclerotic Plaque, But the Same Risk of Heart Attack
Reviewing What is Known of the Mechanisms by Which Calorie Restriction Slows Aging
A View of Age-Related Changes in the Features of Extracellular Vesicles
Polyploidy and Cellular Senescence are Tangled Together
An Aging Clock to Predict Time Until First Alzheimer's Disease Symptoms
Assessing Years of Life Gained by Good Dietary Choices
Obesity Reduces Lifespan of Offspring
A Review of Efforts to Develop Stem Cell Therapies for Neurodegenerative Conditions
The Concept of Brainspan, the Healthspan of the Brain
The Brain as the Rate-Limiting Organ for Longevity
Podocytes in the Kidney Do Not Regenerate and Are Lost with Age
Distribution of Mitochondria is Connected to Function in Aging Neurons
Ube2g1 is Upregulated in Aged Hematopoietic Stem Cells
Relationships Between an Aged Oral Microbiome and Harms Done by Senescent Cells
Aging B Cells are Harmful to Immune Function
OMG as a Marker of Resiliency to Neurodegenerative Processes
Fight Aging! Newsletter, February 23rd 2026
To What Degree Does Cytomegalovirus Contribute to Neurodegenerative Conditions?
Levetiracetam Reduces Amyloid-β Production in the Brain
Aging is Often Overlooked in Mouse Models of Age-Related Conditions
IL-6 as a Measure of Peripheral Inflammation is More Often Elevated in Cognitively Impaired Individuals
Plaque Volume Predicts Risk of Major Adverse Cardiovascular Events
Partial Reprogramming of Neurons Encoding Memory Improves Cognitive Function in Aged Mice
Reduced APOE Expression Improves Bone Regeneration in Aged Mice
IRF7 Expression Drives Instability in Atherosclerotic Plaques
A CAR T Cell Therapy to Target Amyloid Plaques in the Brain
The Aging of Retinal Vasculature Reflects the Aging of the Brain
Functional Impairment in Aging Correlates with Mortality Risk
A Review of the Aging of the Testicles
People Are Still Working on the Senolytic Peptide FOXO4-DRI
Increased O-GlcNAc Transferase Expression as an Approach to Improving Function in the Aging Brain
Inflammatory Glycogen Produced by Gut Microbes Contributes to Neurodegeneration
Fight Aging! Newsletter, February 16th 2026
The ARMOR Study of Fecal Microbiota Transplantation to Treat Aging
The Ethical Case for the Development of Means to Treat Aging as a Medical Condition
Interactions Between Neurons and Glial Cells in the Aging Brain
Position Effect Variegation as a Way to Visualize Age-Related Structural Change of Nuclear DNA
DNA Methylation is Altered with Advancing Age
Reviewing mTOR Inhibition as a Mechanism to Slow Aging
mTOR Inhibitors Reduce DNA Damage and Consequent Cellular Senescence in Immune Cells
Endoplasmic Reticulum Autophagy is Important in Aging
More Evidence for a Prevalent Accumulation of Aggregated Proteins in the Aging Brain
A Reinvigorated Alcor and Growth in Cryonics
BDNF Gene Therapy Improves Cognitive Function in Alzheimer's Model Mice
A Technique for Generating Artificial Lymph Nodes
Reviewing What is Known of Transposon Activity in Aging
tRNA Synthetase Inhibitors Improve Autophagy to Slow Aging
Adoptive Natural Killer Cell Therapy to Destroy Senescent Cells
Fight Aging! Newsletter, February 9th 2026
Arguing for a Higher Heritability of Human Longevity
CUL5 as a Potential Target to Reduce Tau Levels in the Aging Brain
Better Understanding How Misfolded α-Synuclein Moves From Gut to Brain
Perspectives on Aging Research and the Near Future of the Field
Sex Differences in Atherosclerotic Cardiovascular Disease
α-Ketoglutarate Interacts with TET to Regulate Cellular Senescence
Functional Amyloids are Involved in Long Term Memory
The First Clinical Trial of Partial Reprogramming Will Start Soon
Ferroptosis in Alzheimer's Disease is Reduced by Exercise
Considering Autophagy as a Means to Modestly Slow Aging
Phenotypic Age Predicts Mortality Risk in Parkinson's Disease Patients
A Deeper Investigation of Recent Trends in Life Expectancy
Exercise as a Way to Enhance DNA Repair to Slow Aging
Small RNAs Altered in Human Calorie Restriction
The γδ T-Cell Population Changes with Age
Fight Aging! Newsletter, February 2nd 2026
Senolytics as a Treatment for Diabetic Kidney Disease
Changes in the Gut Microbiome are Associated with Mild Cognitive Impairment
Facial Skin Regenerates with Less Scarring, and the Underlying Mechanism Could Be Applied Elsewhere in the Body
Fecal Microbiota Transplantation from Young Mice to Old Mice Improves Intestinal Stem Cell Function
Exercise Reduces Inflammatory TMAO Produced by the Gut Microbiome
Bone Targeted Delivery of Mitochondria Wrapped in Artificial Cell Membranes
Reviewing the Role of Mitochondrial Dysfunction in Alzheimer's Disease
Greater Prevalence of the Favorable APOE-ε2 Variant in People with Preserved Cognitive Function
Heart Disease and Stroke Continue to Account for More than a Quarter of Human Mortality
Results from the Immunis Phase 2 Trial of a Stem Cell Secretome Therapy
Data Suggests Age-Related RNA Processing Alterations in Sperm Cells
Correlation Between Shingles Vaccination and Measures of Biological Aging
ANGPT2 Encourages Blood-Brain Barrier Leakage and Consequent Neurodegeneration
Nuclear Export of HMGB1 Drives Astrocyte Senescence
Hemoglobin in the Progression of Aging
Fight Aging! Newsletter, January 26th 2026
Epoxy-oxylipins as a Potential Means to Reduce Chronic Inflammation
Reduced Mechanical Stimulation in Aged Bone Marrow Contributes to Cell Dysfunction
TNFα Contributes to Age-Related Liver and Intestinal Barrier Dysfunction
Towards Small Molecule Reprogramming as a Basis for Rejuvenation Therapies
Is Ferroptosis Important in Muscle Aging?
An Approach to Measuring Somatic Mosaicism in Solid Tissues
A Brief Tour of Metabolites Shown to Modestly Slow Aging in Animal Studies
Exercise Reduces Immunosenescence
Reversing Loss of Titin Elasticity to Improve the Function of Aged Hearts
PDI Overexpression Improves Vascular Contractility in Aged Blood Vessels
A Discovery Platform for Transcription Factors Capable of Tissue Rejuvenation
Caudate Nucleus Blood Flow and Connectivity Correlate with Grip Strength
Exercise Improves the Aged Gut Microbiome, But Less Effectively as Aging Progresses
An Intracellular Antibody for α-Synuclein Improves Motor Function in Aged Rats
Mechanisms of Aging in the Vasculature and Immune System in the Context of Hypertension
Fight Aging! Newsletter, January 19th 2026
Age-Related Loss of Proteosomal Function Triggers Chronic Inflammation via cGAS-STING
Resistance Exercise Improves Cognitive Function in Older Adults
Is the Role of APOE Variant Status in Alzheimer's Disease Underestimated?
Yet Another New Biotech Company Aims at Regeneration of the Atrophied Thymus
Investigating the Epigenetics of Cellular Senescence in T Cells
A Beneficial Function of TGF-β in Aging
Thoughts on Aging as Damage versus Aging as a Program of Altered Gene Expression
Mechanotransduction via Piezo1 Drives the Benefits of Exercise on Bone Tissue
Common Changes in RNA Splicing and Processing with Age Across Tissues
Reviewing the Use of Fecal Microbiota Transplantation to Treat Parkinson's Disease
LINE-1 RNA Provokes Inflammation to Contribute to Cognitive Dysfunction
Interactions Between Gut Microbiome and Muscle Tissue in the Development of Sarcopenia
Arguing for Sirtuins to be Involved in Known Interventions to Modestly Slow Vascular Calcification
A Short History of the Passage of Anti-Aging Medicine from Fantasy to Scientific Development
An Opinionated View of Current Issues with Aging Clocks
Fight Aging! Newsletter, January 12th 2026
Dementia Risk Varies Between Strong versus Weak Circadian Clock Regulation
Physical Activity Reduces Epigenetic Age and Inflammatory Signaling
Retro Biosciences Starts a Safety Trial for an Autophagy Promoter
In Search of Mechanisms to Explain the Sex Difference in Alzheimer's Disease Outcomes
Reduced Cystathionine γ-lyase Levels May Contribute Meaningfully to Age-Related Neurodegeneration
Improved Drainage of Cerebrospinal Fluid as a Time Critical Treatment for Stroke
A Small Sample of the Complexity of Hair Follicle Aging
Exosomes in Aging and Age-Related Conditions
Evidence for Tau and Amyloid Pathology to Drive White Matter Damage in the Brain
The Saturating-Removal Model of Damage Accumulation and Effects of Lifestyle on Aging
MICOS in the Age-Related Decline of Mitochondrial Function
Modest Reversal of Proteomic Aging via a Structured Program of Exercise
Restoration of Lymphatic Vessel Contractility in Aged Mice
Senescent T Cells Accumulate with Age, Impairing Immune Function
Targeting Mitophagy to Slow Aging
Fight Aging! Newsletter, January 5th 2026
A Rare Reduced Function Mutation in cGAS in a Long-Lived Human Lineage
Succinic Acid Supplementation to Provoke Greater Histone Succinylation
A Framework for Messenger RNA Cancer Vaccine Development
Energy Metabolism Appears Important in Mouse Models of Alzheimer's Disease
Senotherapeutics to Treat Brain Aging
Recommendations for Data Collection in Human Trials of Treatments for Aging
A Look Back at 2025: Progress Towards the Treatment of Aging as a Medical Condition
Continued Efforts to Create Safer Mitochondrial Uncouplers
PIP2 Upregulation Improves Capillary Blood Flow in the Brain
ACE2 is Protective in Hypertension
A Machine Learning Review of the Literature on the Biology and Treatment of Aging
Neuron Death in the Brain Occurs Throughout Life, But Increases with Age
Senolytics Can Treat a Drug-Resistant Form of Epilepsy
Lactic Acid Bacteria Modulate IL-6/STAT3 Signaling to Reduce Age-Related Inflammation
Altering Hepatocyte Metabolism Can Improve the Aged Immune System
Fight Aging! Newsletter, December 29th 2025
Considering the Consequences of the Aging of the Pineal Gland
A Novel Aging Clock Built on Seven Clinical Biomarkers
Another Proteomic Aging Clock for Specific Organs
An Overview of Current Understanding of the Link Between Periodontal Disease and Atherosclerosis
FOXF2 and TIE2 as Targets for the Treatment of Cerebral Small Vessel Disease
Targeting a Specific Amyloid-β Oligomer to Slow Alzheimer's Disease in a Mouse Model
Increased GDF3 Expression with Age Induces Inflammatory Behavior in Macrophages
Further Clinical Trials of a Patch to Deliver New Retinal Cells
Extracellular Vesicle Therapy Restores Pancreatic β-Cell Function in Aged Mice
Inhibiting a Regulator of Increased Glycolysis Kills Senescent Cells
A Prodrug to Trigger Ferroptosis Based Cell Death in Senescent Cells
Mechanisms Involved in the Aging of the Colon
Lipofuscin, an Overlooked Contributing Cause of Neurodegeneration
A Review of Current Approaches to Measure Biological Age
The Potential of Engineered Oncolytic Bateria for the Treatment of Cancer
Fight Aging! Newsletter, December 22nd 2025
Methylglyoxal in Aortic Stiffening in Mice
Mitochondrial Dysfunction as a Contribution to Atrial Fibrillation
Female Sterilization and Male Castration Increase Lifespan Across Vertebrate Species
The Hyaluronidase CEMIP is Involved in Demyelinating Diseases
A Novel Form of Mitochondrial DNA Damage
Modeling a Theoretical Upper Bound on Lifespan Resulting from Somatic Mutation
OTULIN as a Potential Target for Treatment of Tauopathies
Reviewing the Aging of the Oral Microbiome
The Contribution of the Aging Gut Microbiome to Alzheimer's Disease
Aging and Adult Neurogenesis in the Hippocampus
Lysosomal Enlargement in Aging is a Compensatory Response
A Pilot MicroRNA Aging Clock
Making Inroads into the Regulation of Reprogramming Induced Rejuvenation
Terazosin Reduces Endothelial Cell Senescence to Slow Vascular Aging in Mice
Extracellular Matrix Protein Tenascin-C is Important to Muscle Stem Cell Function, But Declines with Age
Fight Aging! Newsletter, December 15th 2025
CD57 as a Marker of Immunological Aging, but Not Immune Cell Senescence
Bifidobacterium Adolescentis is a Beneficial Gut Microbe, Reduced in Number in Cases of Pulmonary Fibrosis
Low Circulating Choline, Obesity, and Alzheimer's Disease
Impairment of Glymphatic Cerebrospinal Fluid Drainage is a Feature of Cerebral Small Vessel Disease
Long Term Treatment with Mesenchymal Stem Cell Extracellular Vesicles Improves Cognitive Function in Rhesus Monkeys
Overexpressing TREX1 in Macrophages Reduces Injury Following Heart Attack
Declining Chaperone Mediated Autophagy in the Aging of Muscle Tissue
Deriving Quality Adjusted Life Year Value from Value of Statistical Life
Senolytic Vaccine Slows Tumor Growth in Animal Models
Senescent Endothelial Cells Involve Mast Cells in the Production of Age-Related Skin Dysfunction
Shingles Vaccination Correlates with Reduced Risk of Alzheimer's Disease
TDP-43 is a Regulator of DNA Repair, and TDP-43 Aggregation Promotes DNA Damage
The Stated Goal of Extending Healthspan But Not Lifespan Was Always a Little Strange
Treatment with Soluble α-Klotho Improves Measures of Aging in Mice
Coronary Artery Disease Correlates with Reduced Myelin Integrity in the Brain
Fight Aging! Newsletter, December 8th 2025
High Variance in Individual Responses is Another Complexity in Attempting to Slow Aging via Metabolic Manipulation
Supplementing Amino Acids in the Ratio Needed for Collagen Production Modestly Reduces Epigenetic Age
15-PGDH Inhibition Spurs Cartilage Regeneration
Exploring DNA Damage Induced Epigenetic Change in a Mouse Model of Alzheimer's Disease
Butyrate Generated by Gut Microbes is Senomorphic in T Cells
Mechanosensing in Monocytes and Macrophages Induces Scar Tissue Formation
A GLP-1 Receptor Agonist Fails to Slow Alzheimer's Disease in a Phase 3 Trial
UBQLN2 is Important in the Aggregation of α-Synuclein in Neurodegenerative Conditions
Extracellular ATP Provokes Brown Adipose Tissue Dysfunction in Aging
The State of IL-10 Signaling May Be Important in the Aging of Hematopoietic Stem Cells
RhoA Inhibition Improves Function in Old Hematopoietic Stem Cells
More Muscle and Less Visceral Fat Correlates with Lower Brain Age
Lysosomal Dysfunction via Acidification Drives Hematopoietic Stem Cell Aging
A Protective Variant of CSF2RB Discovered in Down Syndrome Patients Makes Microglia Less Inflammatory
The Aging of the Intestines is Superficially Similar to Inflammatory Bowel Disease
Fight Aging! Newsletter, December 1st 2025
Molybdenum Disulfide Nanostructures Stimulate Mitochondrial Biogenesis to Enhance Stem Cell Therapy Benefits
CAR-T Therapy Targeting Oxidized LDL Particles Slows Atherosclerotic Plaque Development in Mice
Arginine as a Chaperone to Reduce Amyloid-β Aggregation
Air Pollution Increases the Pace of Loss of Muscle Mass and Strength with Age
Age-Specific Anti-Aging Interventions as Another Example of the Undesirable Complexity of Altering Metabolism
The Myokine Cathepsin B Improves Cognitive Function in an Alzheimer's Mouse Model
Inducing Greater Mitochondrial Respiratory Chain Supercomplex Formation Slows Aging in Mice
Red Blood Cell Metabolic Waste Accumulates in the Aged Spleen to Harm T Cell Function
Mitochondrial Protein CHCHD2 in Parkinson's Disease
Manufacturing Cell Vesicles for Therapy via Membrane Extrusion
Greater Inflammasome Induced IL-1β in Male Periodontitis May Drive Worse Pathology
Modifying the Behavior of Gut Microbes to Generate Colanic Acid Modestly Slows Aging in Nematode Worms
The Onset of Hypertension Causes Detrimental Changes in Cell Behavior Before Blood Pressure Increases
Reviewing Cellular Senescence and Cell Therapy in Cardiovascular Disease
Mechanisms Likely Relevant to Sirtuin 6 Effects on Longevity
Fight Aging! Newsletter, November 24th 2025
Increased Circulating Tyrosine Correlates with Slightly Shorter Lifespan in Men
Degree of Frailty Predicts Risk of Near Future Mortality
Testing a Gain of Function Mutation in Insulin Receptor and IGF-1 Receptor in Mice
Injected Oxytocin Slows Cognitive Decline in Aged Mice
Mixed Results in a Meta-Analysis of Epigenetic Clocks and Frailty
MicroRNA-126 Expression as a Way to Prevent TDP-43 Aggregation in Amyotrophic Lateral Sclerosis
How Much of the Aging of the Gut Microbiome is Induced by Pharmaceutical Use?
Age-Related Sarcopenia Correlates with Cardiovascular and Respiratory Disease
The Relationship Between Gut Microbiome Aging and Kidney Aging
Senolytic Prodrug SSK1 as a Treatment for Osteoarthritis
L-BAIBA Supplementation and Exercise Improves Muscle Function in Old Mice
Clearing Amyloid-β Does Not Improve Glymphatic Drainage in Alzheimer's Patients
Lasting Epigenetic Changes Results from DNA Double Strand Break Repair
Mitochondrially Targeted Fluoropolymer Nanoparticle Induces Mitophagy to Improve Function
A Research Roadmap of Open Problems in Biogerontology
Fight Aging! Newsletter, November 17th 2025
Recombinant FGF19 as a Treatment to Increase Muscle Strength
High Cumulative Blood Pressure Correlates with a Sizable Increase in Dementia Risk
Elastin-like Recombinamers Enable Regrowth of Damaged Enamel
The Endothelial-to-Mesenchymal Transition in the Aging of the Brain's Vasculature
NADP in the Cell Cytosol Influences Vascular Aging
Minimally Invasive Delivery of Tissue Engineered Patches Promotes Regeneration of an Injured Heart
Further Investigation of PU.1 and Microglial Inflammation in the Aging Brain
Modest Levels of Exercise Slow Cognitive Decline in Early Alzheimer's Disease
Adipose Derived Stem Cell Therapy Encourages Regeneration of Bone Fractures
Manufacturing Advances are Key to the Further Development of Extracellular Vesicle Therapies
Progress Towards a Viable Heat Treatment for Dry Macular Degeneration
Chaperone Mediated Autophagy is Necessary for for Brown Adipose Tissue Function
Glial Cell Dysfunction, Both Cause and Consequence of Brain Aging
Reviewing the Mechanisms of Muscle Aging Leading to Sarcopenia
CCNA2 Expression Promotes Regeneration in Older Heart Muscle
Fight Aging! Newsletter, November 10th 2025
Results from a Human Trial of Magnetic Mitohormesis
Persistent Infection Correlations with Increased Risk of Cardiovascular Disease
Inflammation and Maladaptive Extracellular Matrix Remodeling in the Aging Heart
Is Herpes Simplex Virus Type 1 an Important Contribution to Alzheimer's Disease Risk?
A Profile of Sirtuins 1, 3, and 6 in Aging Humans
Aging of the Gut Microbiome as a Contribution to Inflammation and Neurodegeneration
Inhibiting CXCL1-CXCR2 Interactions Slows the Progression of Heart Failure in an Animal Model
The Potential for Stem Cell Derived Extracellular Vesicles to Treat Neurodegenerative Conditions
The Inherited Benefits of Ancestral Life-Extending Stresses Diminish Over Generations
The Brain-Joint Axis, Bidirectional Relationships Between Neurodegeneration and Osteoarthritis
Reducing the Presence of Neutrophil Extracellular Traps as an Approach to Treat Vascular Aging
SAPS3 Inhibition in Mice Increases AMPK to Modestly Improve Metabolism and Slows Aging
The Longevity-Associated Variant of BPIFB4 Can Be Provided Orally to Produce Benefits in Mice
Diluting Dietary Calorie Intake with Non-Digestible Fiber Slows Aging in Mice
Amyloid-β Aggregation Disrupts Circadian Rhythm in Supporting Cells in the Brain
Fight Aging! Newsletter, November 3rd 2025
Human Umbilical Cord Mesenchymal Stem Cell Transplantation as a Senomorphic Therapy
Incompletely Understood Changes in Immunoglobulins Take Place with Age
The Role of Mitochondrial Dysfunction in Sarcopenia
More Evidence for Impaired Cerebrospinal Fluid Drainage to Contribute to Neurodegeneration
Degeneration of the Tectorial Membrane in Age Related Hearing Loss
Misfolded α-Synuclein Breaks Down ATP, Harming Cell Function in the Brain
Deriving Aging Biomarkers from the Dog Aging Project's Metabolomic Data
Mixed Clinical Study Evidence for the Calorie Restriction Mimetic Spermadine to Slow Cognitive Decline
Wearable Device Measurement of Blood Circulation as a Basis for an Aging Clock
A Review of the Present State of Epigenetic Reprogramming to Treat Aging
A Longevity-Reducing Genetic Variation that Replicates in Multiple Study Populations
More Evidence for a Biological Component to the Correlation Between Intelligence and Longevity
Centenarians Exhibit Modestly Greater Genetic Protection from Alzheimer's Disease
PURPL Inhibition Partially Reverses Cellular Senescence
The Usual Concerns Regarding the Growth in Longevity Clinics
Fight Aging! Newsletter, October 27th 2025
Increased FMO3 Expression to Generate More TMAO is a Part of Harmful Adipose Tissue Aging
Visceral Fat Correlates with Progression of Atherosclerosis
Potential Targets to Enhance the Regenerative Capacity of Alveolar Type 2 Cells in the Lungs
Exploring Alternative Splicing as a Determinant of Species Life Span
Lower Circulating BDNF Level Correlates with Greater Cognitive Decline
Reviewing the Ongoing Move from Stem Cell Therapies to Exosome Therapies
Exercise Can Partially Reverse the Age-Related Loss of Muscle Tissue Capillary Density
Reviewing the Development of Senolytic Therapies for Neurodegenerative Conditions
Towards Engineered Mitochondria for Therapy
Recent Progress Towards Measures of the Burden of Cellular Senescence
A Discussion of the Impact of the Gut Microbiome on Aging
Physical Activity Correlates with Improved Benefits from Calorie Restriction in Humans
Chronic Inflammation and Differences in Frailty Between the Sexes
Physical Fitness Correlates with a Slower Onset of Chronic Diseases of Aging
Canagliflozin Reduces Pathology in the Aging Mouse Brain for Male Mice Only
Fight Aging! Newsletter, October 20th 2025
A Discussion of Cellular Senescence in Tumor Associated Macrophages
Nanoparticles for Cancer Vaccines Designed to Promote a Greater Immune Response
Physically Fitter Older Adults Exhibit Better Natural Killer Cell Function
Introducing Naked Mole Rat cGAS Into Mice and Flies to Improve DNA Repair and Treat Aging
First Xenotransplantation of a Genetically Engineered Pig Liver into a Human Volunteer
Centenarian Natural Killer Cells Exhibit Aspects of a Relatively Youthful Phenotype
Engineering Greater Export of Amyloid-β through the Blood-Brain Barrier
Targeting Senescent Cells in the Treatment of Cancer
Targeting STING to Reduce Neuroinflammation
The Role of Cellular Senescence in Cardiovascular Disease
Metabolomic Signatures of Extreme Old Age
Pharmacological Approaches to the Treatment of Skeletal Muscle Aging
Urolithin A as a Senomorphic Treatment
EGCG Targeted to Muscle Cells Enhances Muscle Function in Aged Mice
A 25 Component Blood Biomarker Aging Clock Improves on 9 Component PhenoAge
Fight Aging! Newsletter, October 13th 2025
Delving into the Dysfunction of Aging Neurons Involved in Impairment of Spatial Memory
PP2A-B55α as a Target to Improve Mitochondrial Function
FDA Approval for Mitochondrial Therapeutic Elamipretide, Formerly SS-31
Loss of Coordination of Gene Expression as a Biomarker of Aging
Inhibition of IL-33 Expression in Cartilage to Treat Osteoarthritis
Extracellular Vesicles in Obese Individuals Increase the Aggregation of Amyloid-β in the Brain
Evidence for Amyotrophic Lateral Sclerosis to be an Autoimmune Condition
High Cysteine Intake Boosts Intestinal Stem Cell Function
Helicobacter Pylori Infection Correlates with Risk of Abdominal Aortic Aneurysm
Inhibition of Mitochondrial Calcium Uptake Slows Aging
CHGA Variants Correlate with Longevity
Diet, the Gut Microbiome, and Aging
Type 2 Diabetes Accelerates Age-Related Disease
Mitochondrial Driven Inflammation in the Aging of the Ovaries
A Novel Approach to a Near Universal Cancer Therapy
Fight Aging! Newsletter, October 6th 2025
MT1-MMP Inhibition Restores Some Lost Cognitive Function in Both Aged Mice and Obese Mice
Continued Progress Towards Reversible Vitrification of Organs
Senescent Oligodendrocyte Precursor Cells Contribute to the Aging of the Brain
Towards an Induced Partial Reprogramming Approach to Alzheimer's Disease
Are Socioeconomic Correlations with Disease Explained by Different Lifestyle Choices?
Reviewing the Aging of the Liver
Intermittent Fasting Reduces Effects of Aging on Intestinal Stem Cell Function
A Review of Mechanisms Involved in the Aging of the Heart
Applying a Proteomic Aging Clock to Data from a Very Long-Running Epidemiological Study
PAI-1 Expression is Involved in Muscle Aging