Fight Aging!
Bifidobacterium Adolescentis is a Beneficial Gut Microbe, Reduced in Number in Cases of Pulmonary Fibrosis
Low Circulating Choline, Obesity, and Alzheimer's Disease
Impairment of Glymphatic Cerebrospinal Fluid Drainage is a Feature of Cerebral Small Vessel Disease
Long Term Treatment with Mesenchymal Stem Cell Extracellular Vesicles Improves Cognitive Function in Rhesus Monkeys
Overexpressing TREX1 in Macrophages Reduces Injury Following Heart Attack
Declining Chaperone Mediated Autophagy in the Aging of Muscle Tissue
Deriving Quality Adjusted Life Year Value from Value of Statistical Life
Senolytic Vaccine Slows Tumor Growth in Animal Models
Senescent Endothelial Cells Involve Mast Cells in the Production of Age-Related Skin Dysfunction
Shingles Vaccination Correlates with Reduced Risk of Alzheimer's Disease
TDP-43 is a Regulator of DNA Repair, and TDP-43 Aggregation Promotes DNA Damage
The Stated Goal of Extending Healthspan But Not Lifespan Was Always a Little Strange
Treatment with Soluble α-Klotho Improves Measures of Aging in Mice
Coronary Artery Disease Correlates with Reduced Myelin Integrity in the Brain
Fight Aging! Newsletter, December 8th 2025
High Variance in Individual Responses is Another Complexity in Attempting to Slow Aging via Metabolic Manipulation
Supplementing Amino Acids in the Ratio Needed for Collagen Production Modestly Reduces Epigenetic Age
15-PGDH Inhibition Spurs Cartilage Regeneration
Exploring DNA Damage Induced Epigenetic Change in a Mouse Model of Alzheimer's Disease
Butyrate Generated by Gut Microbes is Senomorphic in T Cells
Mechanosensing in Monocytes and Macrophages Induces Scar Tissue Formation
A GLP-1 Receptor Agonist Fails to Slow Alzheimer's Disease in a Phase 3 Trial
UBQLN2 is Important in the Aggregation of α-Synuclein in Neurodegenerative Conditions
Extracellular ATP Provokes Brown Adipose Tissue Dysfunction in Aging
The State of IL-10 Signaling May Be Important in the Aging of Hematopoietic Stem Cells
RhoA Inhibition Improves Function in Old Hematopoietic Stem Cells
More Muscle and Less Visceral Fat Correlates with Lower Brain Age
Lysosomal Dysfunction via Acidification Drives Hematopoietic Stem Cell Aging
A Protective Variant of CSF2RB Discovered in Down Syndrome Patients Makes Microglia Less Inflammatory
The Aging of the Intestines is Superficially Similar to Inflammatory Bowel Disease
Fight Aging! Newsletter, December 1st 2025
Molybdenum Disulfide Nanostructures Stimulate Mitochondrial Biogenesis to Enhance Stem Cell Therapy Benefits
CAR-T Therapy Targeting Oxidized LDL Particles Slows Atherosclerotic Plaque Development in Mice
Arginine as a Chaperone to Reduce Amyloid-β Aggregation
Air Pollution Increases the Pace of Loss of Muscle Mass and Strength with Age
Age-Specific Anti-Aging Interventions as Another Example of the Undesirable Complexity of Altering Metabolism
The Myokine Cathepsin B Improves Cognitive Function in an Alzheimer's Mouse Model
Inducing Greater Mitochondrial Respiratory Chain Supercomplex Formation Slows Aging in Mice
Red Blood Cell Metabolic Waste Accumulates in the Aged Spleen to Harm T Cell Function
Mitochondrial Protein CHCHD2 in Parkinson's Disease
Manufacturing Cell Vesicles for Therapy via Membrane Extrusion
Greater Inflammasome Induced IL-1β in Male Periodontitis May Drive Worse Pathology
Modifying the Behavior of Gut Microbes to Generate Colanic Acid Modestly Slows Aging in Nematode Worms
The Onset of Hypertension Causes Detrimental Changes in Cell Behavior Before Blood Pressure Increases
Reviewing Cellular Senescence and Cell Therapy in Cardiovascular Disease
Mechanisms Likely Relevant to Sirtuin 6 Effects on Longevity
Fight Aging! Newsletter, November 24th 2025
Increased Circulating Tyrosine Correlates with Slightly Shorter Lifespan in Men
Degree of Frailty Predicts Risk of Near Future Mortality
Testing a Gain of Function Mutation in Insulin Receptor and IGF-1 Receptor in Mice
Injected Oxytocin Slows Cognitive Decline in Aged Mice
Mixed Results in a Meta-Analysis of Epigenetic Clocks and Frailty
MicroRNA-126 Expression as a Way to Prevent TDP-43 Aggregation in Amyotrophic Lateral Sclerosis
How Much of the Aging of the Gut Microbiome is Induced by Pharmaceutical Use?
Age-Related Sarcopenia Correlates with Cardiovascular and Respiratory Disease
The Relationship Between Gut Microbiome Aging and Kidney Aging
Senolytic Prodrug SSK1 as a Treatment for Osteoarthritis
L-BAIBA Supplementation and Exercise Improves Muscle Function in Old Mice
Clearing Amyloid-β Does Not Improve Glymphatic Drainage in Alzheimer's Patients
Lasting Epigenetic Changes Results from DNA Double Strand Break Repair
Mitochondrially Targeted Fluoropolymer Nanoparticle Induces Mitophagy to Improve Function
A Research Roadmap of Open Problems in Biogerontology
Fight Aging! Newsletter, November 17th 2025
Recombinant FGF19 as a Treatment to Increase Muscle Strength
High Cumulative Blood Pressure Correlates with a Sizable Increase in Dementia Risk
Elastin-like Recombinamers Enable Regrowth of Damaged Enamel
The Endothelial-to-Mesenchymal Transition in the Aging of the Brain's Vasculature
NADP in the Cell Cytosol Influences Vascular Aging
Minimally Invasive Delivery of Tissue Engineered Patches Promotes Regeneration of an Injured Heart
Further Investigation of PU.1 and Microglial Inflammation in the Aging Brain
Modest Levels of Exercise Slow Cognitive Decline in Early Alzheimer's Disease
Adipose Derived Stem Cell Therapy Encourages Regeneration of Bone Fractures
Manufacturing Advances are Key to the Further Development of Extracellular Vesicle Therapies
Progress Towards a Viable Heat Treatment for Dry Macular Degeneration
Chaperone Mediated Autophagy is Necessary for for Brown Adipose Tissue Function
Glial Cell Dysfunction, Both Cause and Consequence of Brain Aging
Reviewing the Mechanisms of Muscle Aging Leading to Sarcopenia
CCNA2 Expression Promotes Regeneration in Older Heart Muscle
Fight Aging! Newsletter, November 10th 2025
Results from a Human Trial of Magnetic Mitohormesis
Persistent Infection Correlations with Increased Risk of Cardiovascular Disease
Inflammation and Maladaptive Extracellular Matrix Remodeling in the Aging Heart
Is Herpes Simplex Virus Type 1 an Important Contribution to Alzheimer's Disease Risk?
A Profile of Sirtuins 1, 3, and 6 in Aging Humans
Aging of the Gut Microbiome as a Contribution to Inflammation and Neurodegeneration
Inhibiting CXCL1-CXCR2 Interactions Slows the Progression of Heart Failure in an Animal Model
The Potential for Stem Cell Derived Extracellular Vesicles to Treat Neurodegenerative Conditions
The Inherited Benefits of Ancestral Life-Extending Stresses Diminish Over Generations
The Brain-Joint Axis, Bidirectional Relationships Between Neurodegeneration and Osteoarthritis
Reducing the Presence of Neutrophil Extracellular Traps as an Approach to Treat Vascular Aging
SAPS3 Inhibition in Mice Increases AMPK to Modestly Improve Metabolism and Slows Aging
The Longevity-Associated Variant of BPIFB4 Can Be Provided Orally to Produce Benefits in Mice
Diluting Dietary Calorie Intake with Non-Digestible Fiber Slows Aging in Mice
Amyloid-β Aggregation Disrupts Circadian Rhythm in Supporting Cells in the Brain
Fight Aging! Newsletter, November 3rd 2025
Human Umbilical Cord Mesenchymal Stem Cell Transplantation as a Senomorphic Therapy
Incompletely Understood Changes in Immunoglobulins Take Place with Age
The Role of Mitochondrial Dysfunction in Sarcopenia
More Evidence for Impaired Cerebrospinal Fluid Drainage to Contribute to Neurodegeneration
Degeneration of the Tectorial Membrane in Age Related Hearing Loss
Misfolded α-Synuclein Breaks Down ATP, Harming Cell Function in the Brain
Deriving Aging Biomarkers from the Dog Aging Project's Metabolomic Data
Mixed Clinical Study Evidence for the Calorie Restriction Mimetic Spermadine to Slow Cognitive Decline
Wearable Device Measurement of Blood Circulation as a Basis for an Aging Clock
A Review of the Present State of Epigenetic Reprogramming to Treat Aging
A Longevity-Reducing Genetic Variation that Replicates in Multiple Study Populations
More Evidence for a Biological Component to the Correlation Between Intelligence and Longevity
Centenarians Exhibit Modestly Greater Genetic Protection from Alzheimer's Disease
PURPL Inhibition Partially Reverses Cellular Senescence
The Usual Concerns Regarding the Growth in Longevity Clinics
Fight Aging! Newsletter, October 27th 2025
Increased FMO3 Expression to Generate More TMAO is a Part of Harmful Adipose Tissue Aging
Visceral Fat Correlates with Progression of Atherosclerosis
Potential Targets to Enhance the Regenerative Capacity of Alveolar Type 2 Cells in the Lungs
Exploring Alternative Splicing as a Determinant of Species Life Span
Lower Circulating BDNF Level Correlates with Greater Cognitive Decline
Reviewing the Ongoing Move from Stem Cell Therapies to Exosome Therapies
Exercise Can Partially Reverse the Age-Related Loss of Muscle Tissue Capillary Density
Reviewing the Development of Senolytic Therapies for Neurodegenerative Conditions
Towards Engineered Mitochondria for Therapy
Recent Progress Towards Measures of the Burden of Cellular Senescence
A Discussion of the Impact of the Gut Microbiome on Aging
Physical Activity Correlates with Improved Benefits from Calorie Restriction in Humans
Chronic Inflammation and Differences in Frailty Between the Sexes
Physical Fitness Correlates with a Slower Onset of Chronic Diseases of Aging
Canagliflozin Reduces Pathology in the Aging Mouse Brain for Male Mice Only
Fight Aging! Newsletter, October 20th 2025
A Discussion of Cellular Senescence in Tumor Associated Macrophages
Nanoparticles for Cancer Vaccines Designed to Promote a Greater Immune Response
Physically Fitter Older Adults Exhibit Better Natural Killer Cell Function
Introducing Naked Mole Rat cGAS Into Mice and Flies to Improve DNA Repair and Treat Aging
First Xenotransplantation of a Genetically Engineered Pig Liver into a Human Volunteer
Centenarian Natural Killer Cells Exhibit Aspects of a Relatively Youthful Phenotype
Engineering Greater Export of Amyloid-β through the Blood-Brain Barrier
Targeting Senescent Cells in the Treatment of Cancer
Targeting STING to Reduce Neuroinflammation
The Role of Cellular Senescence in Cardiovascular Disease
Metabolomic Signatures of Extreme Old Age
Pharmacological Approaches to the Treatment of Skeletal Muscle Aging
Urolithin A as a Senomorphic Treatment
EGCG Targeted to Muscle Cells Enhances Muscle Function in Aged Mice
A 25 Component Blood Biomarker Aging Clock Improves on 9 Component PhenoAge
Fight Aging! Newsletter, October 13th 2025
Delving into the Dysfunction of Aging Neurons Involved in Impairment of Spatial Memory
PP2A-B55α as a Target to Improve Mitochondrial Function
FDA Approval for Mitochondrial Therapeutic Elamipretide, Formerly SS-31
Loss of Coordination of Gene Expression as a Biomarker of Aging
Inhibition of IL-33 Expression in Cartilage to Treat Osteoarthritis
Extracellular Vesicles in Obese Individuals Increase the Aggregation of Amyloid-β in the Brain
Evidence for Amyotrophic Lateral Sclerosis to be an Autoimmune Condition
High Cysteine Intake Boosts Intestinal Stem Cell Function
Helicobacter Pylori Infection Correlates with Risk of Abdominal Aortic Aneurysm
Inhibition of Mitochondrial Calcium Uptake Slows Aging
CHGA Variants Correlate with Longevity
Diet, the Gut Microbiome, and Aging
Type 2 Diabetes Accelerates Age-Related Disease
Mitochondrial Driven Inflammation in the Aging of the Ovaries
A Novel Approach to a Near Universal Cancer Therapy
Fight Aging! Newsletter, October 6th 2025
MT1-MMP Inhibition Restores Some Lost Cognitive Function in Both Aged Mice and Obese Mice
Continued Progress Towards Reversible Vitrification of Organs
Senescent Oligodendrocyte Precursor Cells Contribute to the Aging of the Brain
Towards an Induced Partial Reprogramming Approach to Alzheimer's Disease
Are Socioeconomic Correlations with Disease Explained by Different Lifestyle Choices?
Reviewing the Aging of the Liver
Intermittent Fasting Reduces Effects of Aging on Intestinal Stem Cell Function
A Review of Mechanisms Involved in the Aging of the Heart
Applying a Proteomic Aging Clock to Data from a Very Long-Running Epidemiological Study
PAI-1 Expression is Involved in Muscle Aging