Fight Aging!
PURPL Inhibition Partially Reverses Cellular Senescence
The Usual Concerns Regarding the Growth in Longevity Clinics
Fight Aging! Newsletter, October 27th 2025
Increased FMO3 Expression to Generate More TMAO is a Part of Harmful Adipose Tissue Aging
Visceral Fat Correlates with Progression of Atherosclerosis
Potential Targets to Enhance the Regenerative Capacity of Alveolar Type 2 Cells in the Lungs
Exploring Alternative Splicing as a Determinant of Species Life Span
Lower Circulating BDNF Level Correlates with Greater Cognitive Decline
Reviewing the Ongoing Move from Stem Cell Therapies to Exosome Therapies
Exercise Can Partially Reverse the Age-Related Loss of Muscle Tissue Capillary Density
Reviewing the Development of Senolytic Therapies for Neurodegenerative Conditions
Towards Engineered Mitochondria for Therapy
Recent Progress Towards Measures of the Burden of Cellular Senescence
A Discussion of the Impact of the Gut Microbiome on Aging
Physical Activity Correlates with Improved Benefits from Calorie Restriction in Humans
Chronic Inflammation and Differences in Frailty Between the Sexes
Physical Fitness Correlates with a Slower Onset of Chronic Diseases of Aging
Canagliflozin Reduces Pathology in the Aging Mouse Brain for Male Mice Only
Fight Aging! Newsletter, October 20th 2025
A Discussion of Cellular Senescence in Tumor Associated Macrophages
Nanoparticles for Cancer Vaccines Designed to Promote a Greater Immune Response
Physically Fitter Older Adults Exhibit Better Natural Killer Cell Function
Introducing Naked Mole Rat cGAS Into Mice and Flies to Improve DNA Repair and Treat Aging
First Xenotransplantation of a Genetically Engineered Pig Liver into a Human Volunteer
Centenarian Natural Killer Cells Exhibit Aspects of a Relatively Youthful Phenotype
Engineering Greater Export of Amyloid-β through the Blood-Brain Barrier
Targeting Senescent Cells in the Treatment of Cancer
Targeting STING to Reduce Neuroinflammation
The Role of Cellular Senescence in Cardiovascular Disease
Metabolomic Signatures of Extreme Old Age
Pharmacological Approaches to the Treatment of Skeletal Muscle Aging
Urolithin A as a Senomorphic Treatment
EGCG Targeted to Muscle Cells Enhances Muscle Function in Aged Mice
A 25 Component Blood Biomarker Aging Clock Improves on 9 Component PhenoAge
Fight Aging! Newsletter, October 13th 2025
Delving into the Dysfunction of Aging Neurons Involved in Impairment of Spatial Memory
PP2A-B55α as a Target to Improve Mitochondrial Function
FDA Approval for Mitochondrial Therapeutic Elamipretide, Formerly SS-31
Loss of Coordination of Gene Expression as a Biomarker of Aging
Inhibition of IL-33 Expression in Cartilage to Treat Osteoarthritis
Extracellular Vesicles in Obese Individuals Increase the Aggregation of Amyloid-β in the Brain
Evidence for Amyotrophic Lateral Sclerosis to be an Autoimmune Condition
High Cysteine Intake Boosts Intestinal Stem Cell Function
Helicobacter Pylori Infection Correlates with Risk of Abdominal Aortic Aneurysm
Inhibition of Mitochondrial Calcium Uptake Slows Aging
CHGA Variants Correlate with Longevity
Diet, the Gut Microbiome, and Aging
Type 2 Diabetes Accelerates Age-Related Disease
Mitochondrial Driven Inflammation in the Aging of the Ovaries
A Novel Approach to a Near Universal Cancer Therapy
Fight Aging! Newsletter, October 6th 2025
MT1-MMP Inhibition Restores Some Lost Cognitive Function in Both Aged Mice and Obese Mice
Continued Progress Towards Reversible Vitrification of Organs
Senescent Oligodendrocyte Precursor Cells Contribute to the Aging of the Brain
Towards an Induced Partial Reprogramming Approach to Alzheimer's Disease
Are Socioeconomic Correlations with Disease Explained by Different Lifestyle Choices?
Reviewing the Aging of the Liver
Intermittent Fasting Reduces Effects of Aging on Intestinal Stem Cell Function
A Review of Mechanisms Involved in the Aging of the Heart
Applying a Proteomic Aging Clock to Data from a Very Long-Running Epidemiological Study
PAI-1 Expression is Involved in Muscle Aging